Malaria in Africa halved in 15 years

Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa. Understanding the effect of this control effort is vital to inform future control planning. However, the effect of malaria interventions across the varied epidemiological settings of Africa remains poorly understood owing to the absence of reliable surveillance data and the simplistic approaches underlying current disease estimates.

A new study by the Malaria Atlas Project, published in Nature, has quantified the attributable effect of malaria disease control efforts in Africa. We found that Plasmodium falciparum infection prevalence in endemic Africa halved and the incidence of clinical disease fell by 40% between 2000 and 2015. We estimate that interventions have averted 663 million clinical cases since 2000. Insecticide-treated nets, the most widespread intervention, were by far the largest contributor. Although still below target levels, current malaria interventions have substantially reduced malaria disease incidence across the continent.

Full Citation

Bhatt S, Weiss DJ, Cameron E, Bisanzio D, Mappin B, Dalrymple U, Battle K, Moyes CL, Henry A, Ackhoff PA, Wenger EA, Briet O, Penny MA, Smith TA, Bennet A, Yukish J, Eisele TP, Griffin JT, Fergus CA, Lynch M, Lindgren F, Cohen JM, Murray CLJ, Smith DL, Hay SI, Cibulskis RE, Gething PW. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature. 2015 Oct 8;526(7572):207–11.

Press Release

The overall rate of malaria infections in Africa fell by 50 percent between 2000 and 2015, according to a new study from Oxford University. The result is largely attributable to the use of bed nets, the researchers found.

Since 2000, a huge international effort has provided bed nets, insecticides and drugs across Africa to tackle malaria. Yet although these have been shown to work in many small-scale trials, their combined effect has never before been measured across the continent.

In a paper published in Nature, the researchers combine a large database of malaria field surveys from nearly 30,000 sites across sub-Saharan Africa with detailed reconstructions of the interventions that have been used to reduce the disease’s incidence since 2000. Their findings show that the prevalence of infection by Plasmodium falciparum — the parasite that causes the most deadly form of malaria in humans — across the areas of Africa affected by the disease fell by 50 percent between 2000 and 2015.

The researchers, from the Malaria Atlas Project (MAP) at Oxford University’s Department of Zoology, also carried out a series of calculations to establish which interventions had contributed to the dramatic decline in malaria incidence. They found that the combined effect of malaria control since 2000 has been to prevent 663 million cases of the Plasmodium falciparum form of the disease.

Of that total, insecticide-treated bednets were found to have contributed to 68 percent of the impact. Treatment of clinical malaria cases with artemisinin-based combination therapy contributed 22 percent and the use of indoor residual spraying a further 10 percent.

‘Despite the large sums invested in malaria control, our understanding of the impact on the ground has been patchy,’ explains Dr Pete Gething, who leads the MAP team in Oxford. ‘We’ve been able to provide here reliable and compelling evidence of just how big the impact has been and proof that malaria control is one of the smartest ways to spend aid.’

While the findings of the study are positive, Dr Gething points out that much work is still required to fully overcome the disease. ‘300 thousand children still die from malaria in Africa each year and, despite the huge improvements, access to nets, spraying and drugs is still way below where it needs to be,’ he explains. ‘We’ve shown these cheap and effective control measures have made a huge dent in African malaria but this is no time for triumphalism – what’s needed now is a redoubling of efforts to get the job done.’

Modern housing associated with reduced malaria risk in sub-Saharan Africa