Dr. Rosalind Howes

Postdoctoral Researcher


Rosalind is an epidemiologist who investigates the interactions between Plasmodium vivax and human gene polymorphisms. She is a Postdoctoral Researcher based partly with the Malaria Atlas Project in Oxford, and partly in Madagascar in collaboration with Pete Zimmerman and The Center for Global Health and Diseases, Case Western Reserve University.

She completed her BA in Biological Sciences at the University of Oxford in 2007, after which she joined the Malaria Atlas Project as a Research Assistant, and later as a doctoral student. She is interested in the epidemiology of human red blood cell polymorphisms and how these interact with Plasmodium vivax parasites. In particular, she studies the transmission dynamics ofP. vivax in Africa where the majority of the population is Duffy negative and thought to be genetically refractory to infection. Her fieldwork in Madagascar investigates the interactions between the human Duffy antigen and the P. vivax parasites. She is also interested in the epidemiology of G6PD deficiency and how this impacts on primaquine treatment.

Selected Biography

URLDOIBattle KE., Lucas TCD., Nguyen M., Howes RE., Nandi A., Twohig, KA., Pfeffer, DA., Cameron E., Rao PC., Casey D., Gibson HS., Rozier JA., Dalrymple U., Keddie SH., Collins EL., Harris JR., Guerra CA., Thorn MP., Bisanzio D., Fullman N., Huynh CK., Kulikoff X., Kutz MJ., Lopez AD., Mokdad AH., Naghavi N., Nguyen G., Shackelford KA., Vos T., Wang H., Lim SS., Murray CJL., Price RN., Baird JK., Smith DL., Bhatt S., Weiss DJ., Hay SI., Gething PW.,

Mapping the global endemicity and clinical burden of Plasmodium vivax, 2000–17: a spatial and temporal modelling study

The Lancet. June 2019
URLDOIWeiss DJ., Lucas TCD., Nguyen M., Nandi AK., Bisanzio D., Battle KE., Cameron E., Twohig, KA., Pfeffer, DA., Rozier JA., Gibson HS., Rao PC., Casey D., Bertozzi-Villa A., Collins EL., Dalrymple U., Gray N., Harris JR., Howes RE., Kang SY., Keddie SH., May D., Rumisha S., Thorn MP., Barber R., Fullman N., Huynh CK., Kulikoff X., Kutz MJ., Lopez AD., Mokdad AH., Naghavi N., Nguyen G., Shackelford KA., Vos T., Wang H., Smith DL., Lim SS., Murray CJL., Bhatt S., Hay SI., Gething PW.,

Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000–17: a spatial and temporal modelling study

Lancet. June 2019
URLDOIWillie, N, Mehlotra RK., Howes RE., Rakotomanga TA., Ramboarina S., Ratsimbasoa AC., Zimmerman PA.,

Insights into the Performance of SD Bioline Malaria Ag P.f/Pan Rapid Diagnostic Test and Plasmodium falciparum Histidine-Rich Protein 2 Gene Variation in Madagascar

The American Journal of Tropical Medicine and Hygiene. June 2018 98(6): 1683 - 1691.
URLDOIKang SY., Battle KE., Gibson HS., Ratsimbasoa A., Randrianarivelojosia, M, Ramboarina S., Zimmerman PA., Weiss DJ., Cameron E., Gething PW., Howes RE.,

Spatio-temporal mapping of Madagascar’s Malaria Indicator Survey results to assess Plasmodium falciparum endemicity trends between 2011 and 2016

BMC Medicine. May 2018 16 71.
URLDOIWeiss DJ., Nelson A., Gibson HS., Temperley WH., Peedell S., Lieber A., Hancher M., Poyart E., Belchior S., Fullman N., Mappin B., Dalrymple U., Rozier J., Lucas TCD., Howes RE., Tusting LS., Kang SY., Cameron E., Bisanzio D., Battle KE., Bhatt S., Gething PW.,

A global map of travel time to cities to assess inequalities in accessibility in 2015

Nature. January 2018 553 333–336.
URLDOIBaird JK., Battle KE., Howes RE.,

Primaquine ineligibility in anti-relapse therapy of Plasmodium vivax malaria: the problem of G6PD deficiency and cytochrome P-450 2D6 polymorphisms

Malaria Journal. January 2018 17 42.
URLDOIThriemer K., Ley, B, Bobgare, A, Dysoley, L, Alam MS., Pasaribu AP., Sattabongkot J., Jambert E., Domingo GJ., Commons R., Auburn S., Marfurt, J, Devine, A, Aktaruzzaman, MM, Sohel, N, Namgay, R, Drukpa, T, Sharma, SN, Sarawati, E, Samad, I, Theodora, M, Nambanya, S, Ounekham, S, Mudin, RNB, Thakur, GD, Makita, LS, Deray, R, Lee, SE, Boaz, L, Danansuriya, MN, Mudiyanselage, SD, Chinanonwait, N, Kitchakarn, S, Nausien, J, Naket, E, Duc, TN, Manh, HD, Hong, YS, Cheng, Q, Richards, JS, Kusriastuti, R, Satyagraha, A, Noviyanti, R, Ding, XC, Khan, WA, Phru, CS, Guoding, Z, Qi, G, Kaneko, A, Miotto, O, Nguitragool, W, Roobsoong, W, Battle KE., Howes RE., Roca-Feltrer, A, Duparc, S, Bhowmick, IP, Kenangalem, E, Bibit, JA, Barry, A, Sintasath, D, Abeyasinghe, R, Sibley, CH, McCarthy, J, von Seidlein L., Baird JK., Price RN.,

Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group

Malaria Journal. April 2017 16 141.
URLDOIHowes RE., Chan ER., Rakotomanga TA., Schulte S., Gibson J., Zikursh M., Franchard T., Ramiranirina B., Ratsimbasoa A., Zimmerman PA.,

Prevalence and genetic variants of G6PD deficiency among two Malagasy populations living in Plasmodium vivax-endemic areas

Malaria Journal. April 2017 16 139.
URLDOIMehlotra RK., Blankenship DA., Howes RE., Rakotomanga TA., Ramiranirina B., Ramboarina S., Franchard T., Linger MH., Zikursh-Blood M., Ratsimbasoa AC., et al,

Long-term in-vitro culture of Plasmodium vivax isolates from Madagascar maintained in Saimiri boliviensis blood

Malaria Journal. November 2017 16 442.
URLDOIBattle KE., Bisanzio D., Gibson HS., Bhatt S., Cameron E., Weiss DJ., Mappin B., Dalrymple U., Howes RE., Hay SI., et al,

Treatment-seeking rates in malaria endemic countries

Malaria Journal. January 2016 15 20.
URLDOIHowes RE., Battle KE., Mendis KN., Smith DL., Cibulskis RE., Baird JK., Hay SI.,

Global epidemiology of Plasmodium vivax

The American Journal of Tropical Medicine and Hygiene. December 2016 95(6): 15-34.
URLDOIHowes RE., Mioramalala SA., Ramiranirina B., Franchard T., Rakotorahalahy AJ., Bisanzio D., Gething PW., Zimmerman PA., Ratsimbasoa A.,

Contemporary epidemiological overview of malaria in Madagascar: operational utility of reported routine case data for malaria control planning

Malaria Journal. October 2016 15(1): 502.
URLDOIZimmerman PA., Howes RE.,

Malaria diagnosis for malaria elimination

Current Opinion in Infectious Diseases. 2015 28(5): 446-454.
URLDOIPigott DM., Howes RE., Wiebe A., Battle KE., Golding N., Gething PW., Dowell SF., Farag TH., Garcia AJ., Kimball AM., et al,

Prioritising infectious disease mapping

PLoS Neglected Tropical Diseases. June 2015 9(6): e0003756.
URLDOIHowes RE., Reiner Jr. RC., Battle KE., Longbottom J., Mappin B., Ordanovich D., Tatem AJ., Drakeley C., Gething PW., Zimmerman PA., et al,

Plasmodium vivax transmission in Africa

PLoS Neglected Tropical Diseases. November 2015 9(11): e0004222.
DOIBattle KE., Cameron E., Guerra CA., Golding N., Duda KA., Howes RE., Elyazar IRF., Price RN., Baird JK., Reiner RC., et al,

Defining the relationship between Plasmodium vivax parasite rate and clinical disease

Malaria Journal. May 2015 14 191.
URLDOIPiel FB., Howes RE., Patil AP., Nyangiri OA., Gething PW., Bhatt S., Williams TN., Weatherall DJ., Hay SI.,

The distribution of haemoglobin C and its prevalence in newborns in africa

Scientific Reports. April 2013 3
URLDOIHowes RE., Dewi M., Piel FB., Monteiro WM., Battle KE., Messina JP., Sakuntabhai A., Satyagraha AW., Williams TN., Baird JK., et al,

Spatial distribution of G6PD deficiency variants across malaria-endemic regions

Malaria Journal. November 2013 12 418.
URLDOIZimmerman PA., Ferreira MU., Howes RE., Mercereau-Puijalon O.,

Red blood cell polymorphism and susceptibility to Plasmodium vivax

Advances in parasitology. 2013 81 27-76.
URLDOIPiel FB., Howes RE., Nyangiri OA., Moyes CL., Williams TN., Weatherall DJ., Hay SI.,

Online biomedical resources for malaria-related red cell disorders

Human Mutation. July 2013 34(7): 937-944.
URLDOIPiel FB., Patil AP., Howes RE., Nyangiri OA., Gething PW., Dewi M., Temperley WH., Williams TN., Weatherall DJ., Hay SI.,

Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates

Lancet. January 2013 381(9861): 142-151.
URLDOIHowes RE., Battle KE., Satyagraha AW., Baird JK., Hay SI.,

G6PD deficiency: global distribution, genetic variants and primaquine therapy

Advances in Parasitology. 2013 81 133-201.
URLDOIHowes RE., Piel FB., Patil AP., Nyangiri OA., Gething PW., Dewi M., Hogg MM., Battle KE., Padilla CD., Baird JK., et al,

G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map

PLoS Medicine. November 2012 9(11): e1001339.
URLDOIHowes RE., Patil AP., Piel FB., Nyangiri OA., Kabaria CW., Gething PW., Zimmerman PA., Barnadas C., Beall CM., Gebremedhin A., et al,

The global distribution of the Duffy blood group

Nature Communications. April 2011 2 266.
URLDOITatem AJ., Jia P., Ordanovich D., Falkner M., Huang Z., Howes R., Hay SI., Gething PW., Smith DL.,

The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics

The Lancet. Infectious Diseases. January 2016 17(1): 98-107.